Will Ferrell, Zach Galifianakis and Tyler Perry contributed to one of the largest November weekends in box office history.

Megamind – starring Ferrell, Tina Fey and Brad Pitt – topped the competition this weekend with a $46 million take. The animated comedy opened bigger than How to Train Your Dragon – another Paramount/Dreamworks collaboration – did in March ($43.7 million), but smaller than Despicable Me ($56.4 million) did in July.

Todd Phillips’ Due Date, featuring Galifianakis and Robert Downey Jr., also had an impressive open despite landing into second place. The movie, which grossed $32.7 million, had the largest premiere for any R-rated flick in November. (The movie bested the record set by Borat’s $26.4 million in 2006.) The film, though, fell behind The Hangover’s $45 million open in 2009.

For Colored Girls, a Tyler Perry movie without Tyler Perry’s name, was good enough for $19.5 million. Although the ensemble drama nabbed third place, it was the smallest opener for the director since 2008’s The Family That Preys.

Danny Boyle’s 127 Hours was actually the weekend’s best performer. The movie featuring James Franco earned a whopping $66,213 per screen average. That’s the year’s second best number to date. (The Kids are All Right peaked at a $70,282 per-screen average.)

1. Megamind, Dreamworks, $46,016,833 (avg. $11,668)
2. Due Date, Warner Bros., $32,689,406 (avg. $9743)
3. For Colored Girls, Lionsgate, $19,497,324 (avg. $9167)
4. Red, Summit Entertainment, $8,652,086 (avg. $2679)
5. Saw 3D, Lionsgate, $7,731,075 (avg. $2753)
6. Paranormal Activity 2, Paramount, $7,094,742 (avg. $2240)
7. Jackass 3D, Paramount, $4,951,282 (avg. $2287)
8. Secretariat, Disney, $4,067,715 (avg. $1556)
9. Hereafter, Warner Bros., $4,011,397 (avg. $1696)
10. The Social Network, Sony, $3,424,860 (avg. $1841)

(You can review last week's numbers here.)