2KSports posted an update on their official forums, describing a couple of workarounds for the MLB 2K6 freezing issues users are reporting:

In the meantime, our dedicated 2K Sports QA team has tested and confirmed two work-around methods for those consumers who are experiencing the “freeze” issue:

1) Remove or disable the HDD

or,

2) Load three different Xbox 360 games to the main title screen of each game then load Major League Baseball 2K6 on Xbox 360. All three Xbox 360 games must be completely different before loading Major League Baseball 2K6.

Those people with the Xbox 360 hard drive and no memory card to save their games probably won’t find the first solution to be a very good one, and the second is cumbersome to say the least. The 2KSports team is still working on developing an official patch for the game, indicating that there is probably not a media-based issue with the game, but something code-based changed between the review copies and retail versions went out. No mention was made about fixing some of the control issues reported in many of the published reviews for the game.

Read More | 2ksports.com Official Forums.